Şunu aradınız:: desmethylclomipramine (İngilizce - Hırvatça)

the major route of biotransformation of clomipramine is demethylation to desmethylclomipramine.
glavni put biotransformacije klomipramina je demetilacija u desmetilklomipramin.

the active components in vivo are clomipramine and its major metabolite, desmethylclomipramine.
djelatne komponente in vivo su klomipramin i njegov glavni metabolit, desmetilklomipramin.

peak plasma levels of clomipramine and desmethylclomipramine are rapidly reached (approx.
vršne plazmatske razine klomipramina i desmetilklomipramina dostižu se brzo (pribl.

at steady state, the ratio of plasma clomipramine to desmethylclomipramine concentrations is approximately 3:1.
u ravnotežnom stanju, omjer plazmatskih koncentracija klomipramina i desmetilklomipramina iznosio je približno 3:1.

the elimination t1/2 after intravenous administration of clomipramine hydrochloride in dogs was 6.4 hours for clomipramine and 3.6 hours for desmethylclomipramine.
poluvrijeme eliminacije t1/2 nakon intravenske primjene klomipramin hidroklorida u pasa iznosilo je 6,4 sati za klomipramin i 3,6 sati za desmetilklomipramin.

both clomipramine and desmethylclomipramine contribute to the effects of clomicalm: clomipramine is a potent and selective 5-ht reuptake inhibitor while desmethylclomipramine is a potent and selective noradrenaline reuptake inhibitor.
i klomipramin i desmetilklomipramin pridonose učincima clomicalma: klomipramin je potentni i selektivni inhibitor ponovne pohrane 5-ht, dok je desmetilklomipramin potentni i selektivni inhibitor ponovne pohrane noradrenalina.

administration of clomicalm with food causes moderately higher plasma auc values for clomipramine (25%) and desmethylclomipramine (8%) as compared with administration to fasted dogs.
primjena clomicalma s hranom uzrokuje umjereno visoke vrijednosti auc u plazmi za klomipramin (25 %) i desmetilklomipramin (8 %) u usporedbi s primjenom u pasa natašte.

clomipramine is well absorbed (>80%) from the gastrointestinal tract in dogs when administered orally but the systemic bioavailability for clomipramine and desmethylclomipramine is 22-26% due to extensive first pass metabolism by the liver.
klomipramin se dobro apsorbira (> 80 %) iz probavnog sustava pasa kad se primjenjuje peroralno, ali je sistemska bioraspoloživost za klomipramin i desmetilklomipramin 22 - 26 % zbog ekstenzivnog metabolizma prvog prolaska kroz jetru.