Şunu aradınız:: major enzyme (İngilizce - Maltaca)

enzyme increased
żieda fl-enzima tal

enzyme inducers:
indutturi ta’ l- enżimi:

the major enzyme responsible for azilsartan metabolism is cyp2c9.
l-enżima prinċipali responsabbli għall- metaboliżmu azilsartan hija cyp2c9.

esomeprazole inhibits cyp2c19, the major esomeprazole metabolising enzyme.
esomeprazole jinibixxi lil cyp2c19, l-enzim maġġuri li jimmetabolizza lil esomeprazole.

cyp3a4 is a major enzyme responsible for the metabolism of dasatinib.
cyp3a4 huwa enżima maġġuri responsabbli għall-metaboliżmu ta’ dasatinib.

the major cyp450 enzyme involved in the metabolism of telithromycin is cyp3a4.
l-enzima prinċipali ta’ cyp450 involuta fil-metaboliżmu ta` telithromycin hija cyp3a4.

in vitro studies indicate that cyp3a4 is the major enzyme responsible for maraviroc metabolism.
l-istudji in vitro jindikaw li cyp3a4 hija l- enzima prinċipali responsabbli għall-metaboliżmu ta’ maraviroc.

cyp3a4 is the major enzyme responsible for metabolism of the active metabolite id-14283.
cyp3a4 hija l-enzima prinċipali responsabbli għall-metaboliżmu tal-metabolit attiv id-14283.

in vitro studies have shown that cyp3a4 is the major enzyme involved in the metabolism of ketoconazole.
studji in vitro wrew li cyp3a4 hija l-enzima prinċipali involuta fil-metaboliżmu ta’ ketoconazole.

in vitro studies demonstrated that cyp3a was the major enzyme involved in the metabolic clearance of ceritinib.
studji in vitro wrew li cyp3a kien l-enzima ewlenija involuta fit-tneħħija metabolika ta’ ceritinib.

the in vitro results showed that cyp3a4 was the major human p450 enzyme catalysing the biotransformation of imatinib.
ir-riżultati in vitro wrew li cyp3a4 kienet l-enzima prinċipali fil-bniedem tat-tip p450 li tikkatalizza l-biotransformazzjoni ta’ imatinib.

major metabolic pathways of doxycycline have not been identified but enzyme inducers decrease the half-life of doxycycline.
rotot metaboliċi maġġuri ta ’ doxycycline ma ġewx identifikati iżda indutturi ta ’ l- enżimi naqqsu il- half- life ta ’ doxycycline.

dm1 did not inhibit major cyp450 enzymes in vitro.
dm1 ma inibixxiex l-enzimi cyp450 maġġuri in vitro.

trabectedin does not induce or inhibit major cytochrome p450 enzymes.
trabectedin ma jinduċix jew jinibixxix enzimi ċitokromi p450 maġġuri.

in vitro metabolism studies have indicated that cytochrome p450 1a2 (cyp1a2) is the major enzyme responsible for the metabolism of rasagiline.
studji dwar il-metaboliżmu in vitro indikaw li cytochrome p450 1a2 (cyp1a2) huwa l-enzim prinċipali risponsabli għall-metaboliżmu ta’ rasagiline.

cyp3a4 is the major enzyme responsible for ticagrelor metabolism and the formation of the active metabolite and their interactions with other cyp3a substrates ranges from activation through to inhibition.
cyp3a4 huwa l-enzima maġġuri responsabbli għal metaboliżmu ta’ ticagrelor u l-formazzjoni tal- metabolit attiv u l-interazzjonijiet tagħhom ma’ sottostrati oħra ta’ cyp3a ivarjaw minn attivazzjoni għal inibizzjoni.

in vitro studies using human liver microsomes indicate that cyp1a1 is the major enzyme responsible for the 7-hydroxylation of granisetron, whereas cyp3a4 contributes to 9’desmethylation.
studji in vitro bl-użu ta’ mikrosomi tal-fwied tal-bniedem jindikaw li cyp1a1 hi l-enzima maġġuri responsabbli għal 7-hydroxylation ta’ granisetron, filwaqt li cyp3a4 tikkontribwixxi għal 9’desmethylation.

in vitro studies demonstrated that cyp3a4/5 were the major enzymes involved in the metabolic clearance of crizotinib.
l-istudji in vitro wrew li cyp3a4/5 kienu l-enzimi prinċipali involuti fit-tneħħija metabolika ta’ crizotinib.

therefore, there is little potential for interactions with antiretroviral pis and other medicinal products metabolised by major p450 enzymes.
għalhekk mhux probabli li jseħħu interazzjonijiet ma 'pis antiretrovirali u prodotti mediċinali oħra metabolizzati bl- enżimi ewlenien ta ’ p450.

pasireotide is metabolically highly stable and in vitro data show that pasireotide is not a substrate, inhibitor or inducer of any major enzymes of cyp450.
pasireotide huwa mill-aktar stabbli metabolikament u tagħrif in vitro juri li pasireotide mhuwiex sottostrat, inibitur jew induttur ta’ xi enzimi maġġuri ta’ cyp450.