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atripla contains three active substances: efavirenz, which is a non-nucleoside reverse transcriptase inhibitor (nnrti); emtricitabine, which is a nucleoside reverse transcriptase inhibitor; and tenofovir disoproxil, which is a ‘ prodrug ’ of tenofovir, meaning that it is converted into the active substance 7 westferry circus, canary wharf, london e14 4hb, uk tel.