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cilvēkiem, kas saņēma klopidogrelu terapeitiskā devā, nenovēroja ietekmi uz aknu metabolizējošiem enzīmiem.
no effect on hepatic metabolising enzymes was observed in humans receiving clopidogrel at the therapeutic dose.
Son Güncelleme: 2017-04-26
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izteiktās afinitātes dēļ pret unikālu epitopu uz cd38 daratumumaba ietekme uz zāles metabolizējošiem enzīmiem nav gaidāma.
due to the high affinity to a unique epitope on cd38, daratumumab is not anticipated to alter drug-metabolising enzymes.
Son Güncelleme: 2017-04-26
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cilvēkiem, kuriem ir heterozigoti pārmantots ekstensīvs metabolisms, vorikonazola iedarbība vidēji ir 2 reizes lielāka nekā viņu homozigotiem ekstensīvi metabolizējošiem līdziniekiem.
subjects who are heterozygous extensive metabolisers have on average 2-fold higher voriconazole exposure than their homozygous extensive metaboliser counterparts.
Son Güncelleme: 2017-04-26
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trametiniba ietekme uz zāles metabolizējošiem enzīmiem un transporta proteīniem: in vitro un in vivo dati liecina, ka trametinibs neietekmē citu zāļu farmakokinētiku.
effects of trametinib on drug-metabolising enzymes and transporters: in vitro and in vivo data suggest that trametinib is unlikely to affect the pharmacokinetics of other medicinal products.
Son Güncelleme: 2017-04-26
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tās radās lietojot devas, kas vismaz 25 reizes pārsniedz cilvēkam sasniegto iedarbību, lietojot klīnisko devu 75 mg dienā, un bija saistītas ar ietekmi uz aknu metabolizējošiem enzīmiem.
these occurred at doses representing at least 25 times the exposure seen in humans receiving the clinical dose of 75 mg/day and were a consequence of an effect on hepatic metabolising enzymes.
Son Güncelleme: 2017-04-26
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tas saistīts ar to, ka asinszāle inducē medikamentu metabolizējošos enzīmus.
this is due to induction of drug metabolising enzymes by st john’s wort.
Son Güncelleme: 2017-04-26
Kullanım Sıklığı: 3
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