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each capsule contains 100 mg miglustat
každá kapsula obsahuje 100 mg miglustatu.
Son Güncelleme: 2017-04-26
Kullanım Sıklığı: 6
Kalite:
miglustat does not bind to plasma proteins.
miglustat sa neviaže na plazmatické bielkoviny.
Son Güncelleme: 2017-04-26
Kullanım Sıklığı: 3
Kalite:
in healthy subjects miglustat is rapidly absorbed.
u zdravých dobrovoľníkov sa miglustat rýchlo absorbuje.
Son Güncelleme: 2017-04-26
Kullanım Sıklığı: 2
Kalite:
the apparent volume of distribution of miglustat is 83 l.
distribučný objem miglustatu je 83 l.
Son Güncelleme: 2017-04-26
Kullanım Sıklığı: 3
Kalite:
it is not known if miglustat is secreted in breast milk.
nie je známe, či miglustat prechádza do materského mlieka.
Son Güncelleme: 2017-04-26
Kullanım Sıklığı: 3
Kalite:
zavesca is a medicine that contains the active substance miglustat.
zavesca je liek, ktorý obsahuje účinnú látku miglustat.
Son Güncelleme: 2017-04-26
Kullanım Sıklığı: 3
Kalite:
the kinetics of miglustat appear to be dose linear and time independent.
zdá sa, že kinetika miglustatu je dávkovo lineárna a od času nezávislá.
Son Güncelleme: 2017-04-26
Kullanım Sıklığı: 3
Kalite:
there are no adequate data from the use of miglustat in pregnant women.
nie sú k dispozícii dostatočné údaje o použití miglustatu u gravidných žien.
Son Güncelleme: 2017-04-26
Kullanım Sıklığı: 3
Kalite:
the patients were switched to monotherapy with miglustat 100 mg t.i.d.
terapia pacientov bola zmenená na monoterapiu miglustatom 100 mg trikrát denne.
Son Güncelleme: 2017-04-26
Kullanım Sıklığı: 1
Kalite:
pharmacokinetic data indicate increased systemic exposure to miglustat in patients with renal impairment.
farmakokinetické údaje u pacientov s poškodením obličiek naznačujú zvýšenú systémovú expozíciu k miglustatu.
Son Güncelleme: 2017-04-26
Kullanım Sıklığı: 3
Kalite:
the most abundant metabolite in urine was miglustat glucuronide accounting for 5% of the dose.
najčastejším metabolitom v moči bol miglustatglukuronid, ktorý predstavoval 5 % dávky.
Son Güncelleme: 2017-04-26
Kullanım Sıklığı: 3
Kalite:
miglustat did not show any potential for mutagenic or clastogenic effects in the standard battery of genotoxicity tests.
v štandardnom rade testov genotoxicity nevykazoval miglustat žiadny potenciál pre mutagénny alebo klastogénny účinok.
Son Güncelleme: 2017-04-26
Kullanım Sıklığı: 3
Kalite:
six patients had miglustat treatment prematurely discontinued for potential disease worsening, as defined in the study.
Šesť pacientov prerušilo liečbu miglustatom predčasne v súvislosti s potenciálnym zhoršením ochorenia, tak ako to bolo zadefinované v štúdii.
Son Güncelleme: 2017-04-26
Kullanım Sıklığı: 1
Kalite:
miglustat is an inhibitor of glucosylceramide synthase, the enzyme responsible for the first step in the synthesis of most glycolipids.
miglustat je inhibítor enzýmu glukozylceramidsyntázy, ktorý je zodpovedný za prvý krok v syntéze väčšiny glykolipidov.
Son Güncelleme: 2017-04-26
Kullanım Sıklığı: 3
Kalite:
- if you are allergic (hypersensitive) to miglustat or any of the other ingredients of zavesca.
- ak ste precitlivený (alergický) na miglustat alebo niektorú z ďalších zložiek zavescy.
Son Güncelleme: 2012-04-12
Kullanım Sıklığı: 2
Kalite:
the metabolite accounting for this has not been identified, but may accumulate and reach concentrations exceeding those of miglustat at steady state.
metabolit, ktorý je za toto zodpovedný, nebol doposiaľ identifikovaný, môže sa však kumulovať a dosiahnuť koncentrácie prevyšujúce koncentráciu miglustatu v ustálenom stave.
Son Güncelleme: 2017-04-26
Kullanım Sıklığı: 3
Kalite:
zavesca should not be used in people who may be hypersensitive (allergic) to miglustat or any of the other ingredients.
liek zavesca by nemali užívať osoby, ktoré môžu byť precitlivené (alergické) na miglustat alebo inú zložku lieku.
Son Güncelleme: 2012-04-12
Kullanım Sıklığı: 2
Kalite:
miglustat is mainly eliminated by renal excretion, with urinary recovery of unchanged drug accounting for 70-80% of the dose.
miglustat sa vylučuje najmä renálnou exkréciou a množstvo nezmeneného liečiva v moči je 70 – 80 % podanej dávky.
Son Güncelleme: 2017-04-26
Kullanım Sıklığı: 3
Kalite:
reduced growth has been reported in some paediatric patients with niemann-pick type c disease in the early phase of treatment with miglustat where the initial reduced weight gain may be accompanied or followed by reduced height gain.
u niektorých detských pacientov s niemannovou-pickovou chorobou typu c, ktorí boli v počiatočnej fáze choroby liečení miglustatom, bolo hlásené spomalenie rastu, pričom úvodná redukcia prírastku hmotnosti môže byť sprevádzaná alebo nasledovaná redukciou rastu.
Son Güncelleme: 2017-04-26
Kullanım Sıklığı: 1
Kalite:
studies in the rat have shown that miglustat adversely affects spermatogenesis and sperm parameters, and reduces fertility (see sections 4.6 and 5.3).
Štúdie na potkanoch ukázali, že miglustat nepriaznivo ovplyvňuje spermatogenézu, parametre spermií a znižuje plodnosť (pozri časti 4.6 a 5.3).
Son Güncelleme: 2017-04-26
Kullanım Sıklığı: 3
Kalite: