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natalizumab blokerer interaktionen af α4β7 integrinet med det mukosale addressin celleadhæsionsmolekyle-1 (madcam-1).
natalizumab blocks the interaction of α4β7 integrin with the mucosal addressin cell adhesion molecule-1 (madcam-1).
最后更新: 2017-04-26
使用频率: 3
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natalizumab binder sig specifikt til α4β1 integrinet og blokerer derved interaktionen med dets kognate receptor, vaskulært celleadhæsionsmolekyle-1 (vcam-1) og ligand osteopontin, og et variant domæne (alternatively spliced) af fibronektin, connecting segment-1 (cs-1).
specifically, natalizumab binds to the α4β1 integrin, blocking the interaction with its cognate receptor, vascular cell adhesion molecule-1 (vcam-1), and ligands osteopontin, and an alternatively spliced domain of fibronectin, connecting segment-1 (cs-1).
最后更新: 2017-04-26
使用频率: 3
质量: