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6-minutters gangtest (m)
6-minute walk test (meters)

gennemsnitlig ændring i 6-minutters gangtest
mean change in 6-minute walk distance

reduktion af den 6-minutters gangtest på grund af ph
decrease in 6mwd due to ph

den 6 minutters baseline-gangtest viste en moderat motionsindskrænkning:
the baseline 6-minute walk test values reflected a moderate exercise limitation: in the iloprost group the

dyspnømålinger under 6- minutters gangtest viste en forbedring hos patienter, der blev behandlet med tracleer.
dyspnoea measurement during walk tests showed an improvement in tracleer-treated patients.

tabel 2: virkninger af riociguat på den 6-minutters gangtest for chest-1 ved sidste besøg
table 2: effects of riociguat on 6mwd in chest-1 at last visit

det primære slutpunkt for hver undersøgelse var en ændring i 6- minutters gangtest ved 12 uger for den første undersøgelse og 16 uger for den anden undersøgelse.
the primary endpoint for each study was change in 6-minute walk distance at 12 weeks for the first study and 16 weeks for the second study.

forbedringen af 6- minutters gangtest var mærkbar efter 4 ugers behandling og helt tydelig efter 8 ugers behandling og blev opretholdt i op til 28 uger ved en dobbeltblind behandling i en undergruppe af patientpopulationen.
the improvement in walk distance was apparent after 4 weeks of treatment, was clearly evident after 8 weeks of treatment and was maintained for up to 28 weeks of double-blind treatment in a subset of the patient population.

en gangtest, eksempelvis 25 fods testen (timed 25 foot walk; t25fw), anbefales for at vurdere forbedringer efter to uger.
a timed walking test, e.g. the timed 25 foot walk (t25fw), is recommended to evaluate improvement after two weeks.

den 6 minutters baseline- gangtest viste en moderat motionsindskrænkning: i iloprost- gruppen var middelværien 332 meter (median:
the baseline 6-minute walk test values reflected a moderate exercise limitation: in the iloprost group the mean was 332 meters (median value:

patienter, som ved baseline kunne gå mere end 5 meter (m) men mindre end 250 m på 6 minutter i en 12 minutters gangtest eller mindre end 400 m ved 12 minutters tidspunktet, blev rekrutteret i studiet.
patients who could walk more than 5 meters (m) but less than 250 m in 6 minutes of a 12 minute walk test or less than 400 m at the 12 minute time point at baseline were enrolled in the study.

i tilfælde af klinisk forværring (f. eks. mindst 10% reduktion i 6- minutters gangtest i sammenligning med målinger inden behandlingens start) på trods af tracleer behandling i mindst 8 uger (måldosis i mindst 4 uger), bør alternativ behandling overvejes.
in the case of clinical deterioration (e. g., decrease in 6-minute walk test distance by at least 10% compared with pre-treatment measurement) despite tracleer treatment for at least 8 weeks (target dose for at least 4 weeks), alternative therapies should be considered.