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raeb- t pacienti (21- 30% blasti)
clinical efficacy and safety the efficacy and safety of vidaza were studied in an international, multicenter, controlled, open-label, randomised, parallel-group, phase 3 comparative study (aza ph gl 2003 cl 001) in patients with: intermediate-2 and high-risk mds according to the international prognostic scoring system (ipss), refractory anaemia with excess blasts (raeb), refractory anaemia with excess blasts in transformation (raeb-t) and modified chronic myelomonocytic leukaemia (mcmml) according to the french american british (fab) classification system.
no visiem konstatētajiem mds slimības progresēšanas līdz aml gadījumiem pacientiem ar mds sākotnējo klasifikāciju raeb-1 bija lielāka slimības progresēšanas līdz aml iespējamība salīdzinājumā ar zemāka riska mds.
of the cases of mds disease progression to aml that were observed, patients with raeb-1 classification of mds at baseline were more likely to have disease progression to aml compared to lower risk mds.