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in human liver microsomes, abacavir did not inhibit cytochrome p450 isoforms.
abakavir ni zaviral izoform citokroma p450 v humanih jetrnih mikrosomih.

in in vitro studies, daptomycin was not metabolised by human liver microsomes.
v študijah in vitro se daptomicin ni presnavljal s človeškimi jetrnimi mikrosomi.

lapatinib did not significantly inhibit the following enzymes in human liver microsomes:
lapatinib ni pomembneje zaviral naslednjih encimov v humanih jetrnih mikrosomih:

in human liver microsomes, retapamulin was shown to be a strong inhibitor of cyp3a4.
dokazano je, da retapamulin v človeških jetrnih mikrosomih močno zavira cyp3a4.

in vitro experiments with human hepatic microsomes indicate that lopinavir primarily undergoes oxidative metabolism.
poskusi s človeškimi jetrnimi mikrosomi in vitro kažejo, da je presnova lopinavirja predvsem oksidacijska.

in vitro data using human liver microsomes indicate the formation of small amounts of ndemethylated topotecan.
podatki in vitro, dobljeni s pomočjo človeških jetrnih mikrosomov, so pokazali, da nastane majhna količina n-demetiliranega topotekana.

hydroxycarbamide at 30, 100 and 300 µm is not metabolised in vitro by cytochrome p450s of human liver microsomes.
hidroksikarbamid se pri 30, 100 in 300 µm s sistemom citokroma p450 jetrnih mikrosomov in vitro ne metabolizira.

animal studies as well as in vitro experiments with human hepatic microsomes indicated that ritonavir primarily underwent oxidative metabolism.
Študije na živalih in poskusi s človeškimi jetrnimi mikrosomi in vitro kažejo, da je presnova ritonavirja predvsem oksidacijska.

in vitro studies using human liver microsomes indicate that ranolazine is metabolised primarily by cyp3a4, but also by cyp2d6.
Študije in vitro na mikrosomih človeških jeter so pokazale, da ranolazin presnavlja predvsem encim cyp3a4, vendar tudi encim cyp2d6.

in vitro studies using human liver microsomes indicate that cytochrome p450 3a4, 2a6 and 2c9 are involved in the metabolism of montelukast.
24 in vitro študije z mikrosomi človeških jeter kažejo, da so v presnovo montelukasta vpleteni citokrom p450 3a4, 2a6 in 2c9.

metabolism in vitro experiments with human liver microsomes (hlms) indicate that darunavir primarily undergoes oxidative metabolism.
65 presnova in vitro eksperimenti s človeškimi jetrnimi mikrosomi (hlm) kažejo, da se darunavir presnavlja predvsem oksidativno.

in vitro studies using human liver microsomes and cdna-expressed p450 enzymes have shown limited cyp 3a4-mediated metabolism.
Študije in vitro, pri katerih so uporabili človeške mikrosome jeter in s cdna izražene encime p450, so pokazale omejeno presnovo preko encima cy p3a4.

progestogens and estrogens inhibit a variety of p450 enzymes (e. g., cyp 3a4, cyp 2c19) in human liver microsomes.
cyp 3a4, cyp 2c19).

in vitro inhibit ion studies in human liver microsomes suggest that cytochrome p450 (cyp) 1a2, 2c19 and 3a4 are involved in leflunomide metabolism.
Študije zaviranja in vitro z mikrosomi humanih jeter kažejo, da so v presnovo leflunomida vključeni citokromi p450 (cyp) 1a2, 2c19 in 3a4.

freshly isolated or cultured hepatocytes and subcellular fractions (e.g. microsomes and cytosol or s9 fraction) from liver may be used to study possible metabolites.
za preučevanje mogočih metabolitov se lahko uporabijo sveže izolirani ali kultivirani hepatociti in podcelične frakcije (npr. mikrosomi in citosolska frakcija ali frakcija s9) iz jeter.

results of in vitro studies using both human and rat liver microsome preparations indicated no cytochrome p450 enzyme mediated metabolism of ribavirin.
izsledki študij in vitro z uporabo pripravkov človeških in podganjih jetrnih mikrosomov niso pokazali nikakršne presnove ribavirina prek encimov citokroma p450.