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by acting as a ligand trap, aflibercept prevents binding of endogenous ligands to their cognate receptors and thereby blocks receptor mediated signaling.
toimides ligandipüünisena, hoiab aflibertsept ära endogeensete ligandite seondumise nende retseptoritega ning blokeerib seeläbi signaali edastamise retseptorite vahendusel.
aflibercept acts as a soluble decoy receptor that binds vegf-a and plgf with higher affinity than their natural receptors, and thereby can inhibit the binding and activation of these cognate vegf receptors.
aflibertsept toimib lahustuva retseptorina, mis seob vegf-a-d ja plgf-i suurema afiinsusega kui nende loomulikud retseptorid, ja suudab seega takistada viimaste seondumist vegf-i retseptoritega ning nende aktiveerumist.