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bij klinisch onderzoek bracht lasofoxifen geen verandering teweeg in het metabolisme van dextromethorfan (cyp2d6-substraat) en chlorzoxazon (cyp2e1-substraat) of de farmacokinetiek van warfarine (cyp2c9- substraat), methylprednisolon (cyp3a4 substraat) en digoxine (mdr1 p- glycoproteïnesubstraat).
in clinical studies, lasofoxifene did not alter the metabolism of dextromethorphan (cyp2d6 substrate) and chlorzoxazone (cyp2e1 substrate) or the pharmacokinetics of warfarin (cyp2c9 substrate), methylprednisolone (cyp3a4 substrate) or digoxin (mdr1 p-glycoprotein substrate).
最后更新： 2017-04-26
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