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tcis
tcis

tcis n = 408
endpoint

75 mg/m2 de docetaxel (t), seguido inmediatamente de 75 mg/ m2 de cisplatino (cis) durante 30-60 minutos, cada 3 semanas (tcis), en otro grupo que recibió una perfusión de 1 hora con 75 mg/m2 de docetaxel en combinación con carboplatino (cb) (auc de 6 mg/ml.min) durante 30-60 minutos, cada 3 semanas, ó 25 mg/m2 de vinorelbina (v), administrada durante 6-10 minutos en los días 1,8, 15, 22, seguido de 100 mg/m2 de cisplatino administrado en el día 1 de los ciclos repetido cada 4 semanas (vcis).
in a phase iii study, 1218 patients with unresectable stage iiib or iv nsclc, with kps of 70% or greater, and who did not receive previous chemotherapy for this condition, were randomised to either docetaxel (t) 75 mg/m2 as a 1 hour infusion immediately followed by cisplatin (cis) 75 mg/m2 over 30-60 minutes every 3 weeks (tcis), docetaxel 75 mg/m2 as a 1 hour infusion in combination with carboplatin (auc 6 mg/ml. min) over 30-60 minutes every 3 weeks, or vinorelbine (v) 25 mg/m2 administered over 6-10 minutes on days 1, 8, 15, 22 followed by cisplatin 100 mg/m2 administered on day 1 of cycles repeated every 4 weeks (vcis).