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introduction epithelial ovarian cancer (eoc) is the eighth most prevalent cause of cancer deaths among women worldwide [1]. approximately 80 % of patients with primary disease respond to surgery and chemotherapy, but 60–80 % of these patients will present with recurrent disease 6 months to 2 years post-treatment [2]. eoc is characterized by unusual biological behavior differing from the classic and well-studied pattern of cancer cell dissemination and metastasis through vasculature. once ovarian cancer (oc) cells have detached as single cells or clusters from the primary ovarian tumor, they are disseminated throughout the abdominal cavity by peritoneal fluid or ascites and often form aggregated tumor cells or multicellular tumor spheroid-like structures (mcts) which could attach to mesothelium, invade the peritoneum and initiate metastatic tumor growth [3]. it has been demonstrated that these spheroids in ascites are capable of tumorigenesis in vivo and are chemoresistant in vitro [4,5]. the cell-cell adhesion and cell-ecm interacting molecules, including integrins and cadherins, play a role in the formation and metastasis of ovarian cancer mcts
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最后更新： 2019-12-21
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