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15 lepirudinei, datorită deficitelor de coagulare secundare scăderii sintezei factorilor de coagulare dependenţi de vitamina k. – formarea de anticorpi anti- hirudină a fost observată la aproximativ 40% dintre pacienţii cu tih de tip ii şi a fost raportată în special ca fiind asociată cu o perioadă de tratament mai mare de cinci zile.
serious liver injury (e. g. liver cirrhosis) may enhance the anticoagulant effect of lepirudin due to coagulation defects secondary to reduced generation of vitamin k-dependent coagulation factors. – formation of anti-hirudin antibodies was observed in about 40% of hit type ii patients and have been reported especially with a treatment period exceeding five days.
