Sie suchten nach: glukuronoziltransferaz (Slowenisch - Englisch)

ataluren se presnavlja s konjugacijo preko encimov uridin difosfat glukuronoziltransferaz (ugt), predvsem preko ugt1a9 v jetrih in črevesju.
ataluren is metabolized by conjugation via uridine diphosphate glucuronosyltransferase (ugt) enzymes, predominantly ugt1a9 in liver and intestine.

Študije in vitro / in vivo kaţejo, da so v presnovo izavukonazola vključeni cyp3a4, cyp3a5 in kasneje uridin difosfat-glukuronoziltransferaz (ugt).
in vitro / in vivo studies indicate that cyp3a4, cyp3a5, and subsequently uridine diphosphate- glucuronosyltransferases (ugt), are involved in the metabolism of isavuconazole.

kar zadeva jetrne mikrosome, pitolizant bistveno ne zavira delovanja citokromov cyp1a2, cyp2c9, cyp2c19, cyp2c8, cyp2b6, cyp2e1 in cyp3a4 ter izooblik uridin difosfat glukuronoziltransferaz ugt1a1, ugt1a4, ugt1a6, ugt1a9 in ugt2b7 pri koncentracijah do 13,3 µm, kar je bistveno večja koncentracija od tistih, ki se pojavijo pri terapevtskih odmerkih.
on liver microsomes, pitolisant does not significantly inhibit the activities of the cytochromes cyp1a2, cyp2c9, cyp2c19, cyp2c8, cyp2b6, cyp2e1 or cyp3a4 and of uridine diphosphate glucuronosyl transferases isoforms ugt1a1, ugt1a4, ugt1a6, ugt1a9 and ugt2b7 up to the concentration of 13.3 µm, a level considerably higher than the levels achieved with therapeutic dose.