Results for norbuprenorfin translation from Czech to English

norbuprenorfin
(atazanavir 300 mg qd with ritonavir 100 mg qd)

norbuprenorfin:
norbuprenorphine:

auc: ↓ 50% norbuprenorfin:
auc: ↓ 50% norbuprenorphine:

buprenorfin, norbuprenorfin, metabolity glukuronidů
analgesics buprenorphine norbuprenorphine glucuronide metabolites

↑ norbuprenorfin auc: 1,62 (1,30; 2,02)
↑ buprenorphine auc: 1.37 (1.24, 1.52)

norbuprenorfin auc ↑ 105% norbuprenorfin cmax ↑ 61% norbuprenorfin cmin ↑ 101%
norbuprenorphine auc ↑105% norbuprenorphine cmax ↑61% norbuprenorphine cmin ↑101

norbuprenorfin ↑2. 05 ↑1. 61 ↑2. 01 mechanizmem interakce je inhibice cyp3a4 a ugt1a1.
norbuprenorphine ↑ 2.05 ↑ 1.61 ↑ 2.01 the mechanism of interaction is cyp3a4 and ugt1a1 inhibition.

inhibitory cyp3a4: studie interakce buprenorfinu s ketokonazolem (účinným inhibitorem cyp3a4) ukázaly zvýšené cmax a auc (plocha pod křivkou) buprenorfinu (přibližně o 50 %, respektive 70 %) a v menší míře norbuprenorfinu.
cyp3a4 inhibitors: an interaction study of buprenorphine with ketoconazole (a potent inhibitor of cyp3a4) resulted in increased cmax and auc (area under the curve) of buprenorphine (approximately 50 % and 70 % respectively) and, to a lesser extent, of norbuprenorphine.