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ved høje lokale vævskoncentrationer af gadobutrol medfører t2 - effekten en nedsat signalstyrke.
with high local tissue concentrations of gadobutrol the t2 effect results in a lessening of signal intensity.
Last Update: 2012-04-12
Usage Frequency: 6
Quality:
de fleste af de observerede ændringer indtraf efter længerevarende daglig indgift efterfulgt af stigninger i plasma- og vævskoncentrationer af det aktive stof.
most of the observed changes occurred after prolonged daily dosing and subsequent increases in plasma and tissue concentrations of the active substance.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
hos rotter passerede retigabin og/eller dets metabolitter placenta, hvilket resulterede i vævskoncentrationer, der var af samme størrelsesorden hos moderdyrene og i fostrene.
in rats, retigabine and/or its metabolites crossed the placenta resulting in tissue concentrations that were similar in dams and foetuses.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
i in vivo- undersøgelser hos rotter inducerede atazanavir ikke mikronukleus i knoglemarv, dna- beskadigelse i duodenum (comet assay) eller uplanlagt dna- reparation i leveren ved plasma - og vævskoncentrationer, der overskrider dem, der var klastogene in vitro.
in in vivo studies in rats, atazanavir did not induce micronuclei in bone marrow, dna damage in duodenum (comet assay), or unscheduled dna repair in liver at plasma and tissue concentrations exceeding those that were clastogenic in vitro.
Last Update: 2012-04-12
Usage Frequency: 7
Quality: