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studies in rabbits demonstrated that the topically administered nepafenac is distributed locally from the front of the eye to the posterior segments of the eye (retina and choroid).
uuringud küülikutel on näidanud, et paikselt manustatud nepafenak jaotub paikselt silma eesmistest segmentidest silma tagumistesse segmentidesse (võrkkest ja soonkest).
pharmacodynamic effects the majority of hydrolytic conversion is in the retina/ choroid followed by the iris/ ciliary body and cornea, consistent with the degree of vascularised tissue.
farmakodünaamilised toimed hüdrolüüs toimub peamiselt reetinas/ koroideas, millele järgnevad iiris/ tsiliaarkeha ja sarvkest vastavalt kudede vaskularisatsiooni astmele.
levels of ocular toxicity in healthy rabbits and monkeys, particularly on the retina/choroid, correlated with medicinal product dose, light dose, and time of light treatment.
tervetel küülikutel ja ahvidel korreleerus silma-, eriti reetina/soonkesta toksilisus ravimi annuse, valguse annuse ja valgusravi ajaga.