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an increase in the volume of adipocytes can therefore be considered to result in compression of interlobular veins.
on peut dès lors envisager que l'augmentation de volume des adipocytes se traduit par une compression des veines interlobulaires.
the principal change observed in the lungs is oedema, which affects not only the alveoli, hut also the interlobular septa.
la principale altération du poumon est l'oedème qui atteint non seulement les alvéoles mais encore les cloisons interlobulaires.
the use according to any one of claims 1 to 5, wherein said functional gene is introduced into the interlobular ducts of the pancreas via a retrograde filling of said ducts.
utilisation selon l'une quelconque des revendications 1 à 5, dans laquelle ledit gène fonctionnel est introduit dans les canaux interlobulaires du pancréas par un remplissage rétrograde desdits canaux.
on postmortem of the third muskox at day 97 p.i., not all adult parasites were within typical cysts; two were found free in interlobular septa.
l'examen postmortem du troisième animal, au jour 97 de l'infection, a révélé que les parasites adultes n'étaient pas tous dans des kystes typiquees, puisque deux d'entre eux ont été trouvés libres dans les septums interlobulaires.
use of a functional gene associated with a carrier capable of transferring said gene into pancreatic ductal epithelial cells for the preparation of a pharmaceutical composition for treating a primary hepatic or pancreatic disease in a patient by introducing said functional gene into the pancreatic ductal epithelial cells of a patient via the interlobular ducts of the pancreas.
utilisation d'un gène fonctionnel associé à un véhicule capable de transférer ledit gène dans des cellules épithéliales du canal pancréatique pour la préparation d'une composition pharmaceutique destinée au traitement d'une maladie hépatique ou pancréatique primaire chez un patient en introduisant ledit gène fonctionnel dans les cellules épithéliales du canal pancréatique d'un patient par les canaux interlobulaires du pancréas.
secrétaire médicaliver dysfunction in patients with celiac disease was first described in studies from the 1970s.10 celiac disease is associated with two different types of liver dysfunction: cryptogenic liver disorders, usually with positive response to gfd; and autoimmune disorders. cryptogenic liver disorders can range from mild to severe hepatitis, and usually present with isolated increase in aminotransferases.11,12 histology of the liver typically shows preserved architecture with a mild mononuclear infiltrate of the portal and lobular tract, and hyperplasia of the kupffer cells. intraepithelial lymphocytes can be seen in interlobular bile ducts as well as small bowel.13 hyperplasia of kupffer cells is typical of nonspecific reactive hepatitis, also known as celiac hepatitis.11,12,14 the term ‘celiac hepatitis’ specifically refers to liver injury in patients with confirmed celiac disease that resolves after introduction of gfd.3 conversely, in autoimmune liver diseases (ailds), histology of the liver shows mononuclear and eosinophilic infiltration of the portal tract in the presence of characteristic circulating autoantibodies (anti-nuclear ana, anti-smooth muscle antibody (asma), anti-liver kidney microsomal lkm1), suggestive of autoimmune disease. ailds usually require combination of gfd and immunosuppressive therapy as treatment. it is unknown whether cryptogenic and autoimmune liver disorders have different pathogeneses or constitute a spectrum of the same disorder.11 liver dysfunction in celiac disease can manifest with nonspecific symptoms of hepatitis, such as malaise and fatigue. however, patients are usually asymptomatic and may not have any celiac disease manifestations or symptoms.3,15 elevations in aminotransferases are usually mild to moderate, with an aspartate aminotransferase (ast):alanine aminotransferase (alt) ratio usually less than 1. alkaline phosphatase (alp) can be normal or elevated in around 4–20% of cases. bilirubin and gamma-glutamyl transferase (ggt) are often normal, but prothrombin time and albumin levels are nonspecific and could be altered due to malabsorption.3 signs such as jaundice, ascites, encephalopathy or portal hypertension usually indicate advanced liver disease, which can be from another co-existing liver condition. wakim-fleming et al.16 tested for celiac disease in 204 patients with biopsy-proven cirrhosis. five patients showed positive for celiac disease with duodenal biopsy. these patients had cirrhosis secondary to non-alcoholic steatohepatitis, cryptogenic liver disease, primary sclerosing cholangitis (psc), autoimmune hepatitis (aih), and alcoholic liver disease. four of these patients were started on gfd and followed for 2 years, the last patient with alcoholic liver disease passed away. only the patient with aih received additional treatment with prednisone. all experienced biochemical/serological resolution and normalization of small bowel histology after treatment. model for end-stage liver disease scores improved in three of the patients.16 that study suggested that liver damage from celiac disease can be simultaneous to liver damage from another pathology, and biochemical abnormalities can be corrected after gfd incorporation. however, it cannot be determined whether gfd alone would have corrected the elevated aminotransferases. other measures could have played a role, such as weight loss in the non-alcoholic steatohepatitis patient or cessation of alcohol or hepatotoxic drugs.le
secrétaire médicale
Last Update: 2021-11-01
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