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the first hcov-229e strain was isolated from the respiratory tract of patients with upper respiratory tract infection in the year of 1966, and was subsequently adapted to grow in wi-38 lung cell lines.
strain hcov-229e pertama telah diasingkan daripada saluran pernafasan pesakit yang menghidapi jangkitan kuman pada saluran pernafasan atas pada tahun 1966, dan seterusnya telah disesuaikan untuk tumbuh di dalam barisan sel paru-paru wi-38.