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lipofuscin
lipofuscina
Last Update: 2014-12-09
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lipofuscin storage disease
lipofuscinose ceróide neuronal
Last Update: 2014-12-09
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disease, lipofuscin storage
liopofuscinose ceróide neuronal ne
Last Update: 2014-12-09
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lipofuscin [chemical/ingredient]
lipofuscina
Last Update: 2014-12-09
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in all patients, a moderate amount of lipofuscin granules were noticed, especially close to the poles of cardiomyocyte nuclei.
em todos os pacientes, foi observada moderada quantidade de grânulos de lipofuscina, particularmente, próximo aos pólos dos núcleos dos cardiomiócitos.
elevated liver enzymes and histological changes in the liver consisting in dose–related lipofuscin accumulation in hepatocytes were reported in rats and dogs after repeated administration of ketoconazole.
foram notificadas enzimas hepáticas elevadas e alterações histológicas no fígado, consistindo em acumulação de lipofuscina relacionada com a dose em hepatócitos de murídeos e cães após a administração repetida de cetoconazol.
aside from a large lipid content, lipofuscin is known to contain sugars and metals, including mercury, aluminum, iron, copper and zinc.
além de um grande teor de lípidos, lipofuscina é pode conter açúcares e de metais, incluindo o mercúrio, alumínio, ferro, cobre e zinco.
these included: dose-dependent adrenocortical toxicity (lipofuscin pigment accumulation and/ or parenchymal cell loss) in rats after 104 weeks at 20 to 60 mg/ kg/ day (3 to 10 times the mean steady-state auc at the maximum recommended human dose) and increased adrenocortical carcinomas and combined adrenocortical adenomas/ carcinomas in female rats at 60 mg/ kg/ day (10 times the mean steady-state auc at the maximum recommended human dose).
estes incluiram: toxicidade adrenocortical dose- dependente (acumulação do pigmento lipofuscina e/ ou perda celular no parênquima) em ratos após 104 semanas com 20 a 60 mg/ kg/ dia (3 a 10 vezes a auc do estado de equilíbrio média na dose humana máxima recomendada) e aumento dos carcinomas adrenocorticais e adenomas/ carcinomas adrenocorticais combinados no rato fêmea com 60 mg/ kg/ dia (10 vezes a auc do estado de equilíbrio média na dose humana máxima recomendada).