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chlorodeoxyadenosine
kladribin
Last Update: 2014-12-09
Usage Frequency: 9
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metabolism intracellular cladribine is metabolised predominantly by deoxycytidine kinase to 2-chlorodeoxyadenosine-5'-monophosphate that is further phosphorylated to the diphosphate by nucleoside monophosphate kinase and to the active metabolite 2-chlorodeoxyadenosine- 5'-triphosphate (cdatp) by nucleoside diphosphate kinase.
metabolism intracellulärt kladribin metaboliseras huvudsakligen av deoxycytidinkinas till 2- klorodeoxyadenosin - 5 '- monofosfat, som i sin tur fosforyleras till difosfatet av nukleosidmonofosfatkinas och till den aktiva metaboliten 2- klorodeoxyadenosin- 5' - trifosfat (cdatp) av nukleosiddifosfatkinas.
Last Update: 2012-04-11
Usage Frequency: 1
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