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free radicals may also be produced by direct contact of agnps with the microorganisms that damage and permeabilize their cell membranes and can ultimately promote cell death.
agnps have been shown to bind, transpose, and accumulate in the cell wall of microorganisms (bacteria or fungi), which may lead to dramatic morphological changes in the cell membrane followed by disruption caused by the release of intracellular components (including biomolecules and ions) and ultimately causing cell death (sondi and salopek sondi, 2004; yamanaka et al., 2005).
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