Results for successiv translation from Maltese to English

Ġew identifikati ħames passaġġi minn fejn lasofoxifene jiġi mmetabolizzat: ditossifikazzjoni diretta mill- fwied fejn jinqabad il-glucuronic acid biex jitneħħa mill-ġisem; ditossifikazzjoni diretta mill-fwied fejn jinqabad il-kubrit biex jitneħħa mill-ġisem;–idrossilazzjoni mal-parti phenyl tertaline tal-molekula (b’metaboliżmu successiv konjugattiv ta’ intermedjarji ta’ catechol bil- proċess ta’ methylation u glucuronidation); ossidazzjoni fiċ-ċirku pyrrolidine; u phenyl idrossilazzjoni.
five metabolic pathways of lasofoxifene have been identified: direct glucuronidation; direct sulfation; hydroxylation at the phenyl tetraline moiety (with subsequent conjugative metabolism of the catechol intermediates by methylation and glucuronidation); oxidation at the pyrrolidine ring; and phenyl hydroxylation.