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natalizumab bindes spesifikt til alfa4beta1-integrinet og blokkerer interaksjonen med kognatreseptoren, vcam-1 (vascular cell adhesion molecule-1), binder til osteopontin og et variantdomene (”alternatively spliced”) av fibronektin, cs-1 (connecting segment-1).
specifically, natalizumab binds to the α4β1 integrin, blocking the interaction with its cognate receptor, vascular cell adhesion molecule-1 (vcam-1), and ligands osteopontin, and an alternatively spliced domain of fibronectin, connecting segment-1 (cs-1).