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doentes com conhecida ausência completa de atividade da di-hidropirimidina desidrogenase (dpd) (ver secção 4.4),
chez les patients présentant une absence complète d’activité de la dihydropyrimidine déshydrogénase (dpd) (voir rubrique 4.4),
in vitro, topotecano não inibiu as enzimas p450 humanas cyp1a2, cyp2a6, cyp2c8/ 9, cyp2c19, cyp2d6, cyp2e, cyp3a ou cyp4a, nem inibiu as enzimas citosólicas humanas di- hidropirimidina ou xantina- oxidase.
in vitro, topotécan n'a inhibé chez l'homme ni les enzymes p450 cyp1a2, cyp2a6, cyp2c8/ 9, cyp2c19, cyp2d6, cyp2e, cyp3a, ou cyp4a, ni les enzymes cytosoliques (la dihydropyrimidine ou la xanthine oxydase).