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in vitro human microsomal studies and in in vivo studies indicate that enfuvirtide is not an inhibitor of cyp450 enzymes.
humane mikrosomale in vitro-studier og in vivo- studier tyder på, at enfuvirtid ikke hæmmer cyp450-enzymer.
tests must be performed, in the presence and absence of a microsomal mammalian preparation, for metabolic activation.
undersøgelserne foretages i tilstedeværelse eller fravær af et mikrosomalt pattedyrspræparat til metabolisk aktivering.
in vitro studies using human liver microsomal preparations suggest that cyp 1a2 is the principal isozyme involved in the initial oxidative metabolism of riluzole.
in vitro studier med anvendelse af human lever mikrosomale præparationer antyder, at cyp 1a2 er det principielle isoenzym involveret i den initiale oxidative metabolisme af riluzole.
iaa and aa had the same effects on hepatic microsomal udp-glucuronyltransferase (neumann, cm. et al 1988).
las og s havde samme virkning på hepatisk mikrosomal udpglucuronyltransferase (neumann, cm. et al. 1988).
metabolism in vitro studies have demonstrated that there is no or limited liver microsomal mediated metabolism of daptomycin in humans and that cyp450 involvement in daptomycin metabolism is minimal.
metabolisme in vitro- forsøg har vist, at der kun er begrænset eller ingen mikrosomal- medieret levermetabolisme af daptomycin hos mennesker, og at cyp450- systemet kun er minimalt involveret i daptomycins metabolisme.
the active substance in yarvitan, mitratapide, works in the gut by blocking a protein (the microsomal triglyceride transfer protein).
det aktive stof i yarvitan, mitratapid, virker i tarmen ved at blokere et protein (mikrosomalt triglycerid-transportprotein).
data from in vitro studies using human liver microsomal preparations indicate that entacapone inhibits cytochrome p450 2c9 (ic50 ~ 4 µm).
data fra in vitro forsøg, hvor der er anvendt humant lever mikrosomale præparationer, indikerer, at entakapon hæmmer cytokrom p450 2c9 (ic50 ~ 4 µm).
sildenafil is cleared predominantly by the cyp3a4 (major route) and cyp2c9 (minor route) hepatic microsomal isoenzymes.
sildenafil metaboliseres hovedsageligt af cyp3a4 (primær vej) og cyp2c9 (sekundær vej) mikrosomale leverisoenzymer.
in addition microsomes may be useful to identify the specific microsomal enzymes involved in the metabolism of the test chemical which can be relevant in species extrapolation (see also paragraph 56).
mikrosomer kan desuden hjælpe med at identificere de specifikke mikrosomenzymer, der er involveret i metabolismen af testkemikaliet, hvilket kan være relevant ved ekstrapolering mellem arter (se også afsnit 56).
in in vitro human microsomal and hepatocyte studies, hydrolysis of the amide group of the c-terminus amino acid, phenylalanine results in a deamidated metabolite and the formation of this metabolite is not nadph dependent.
i humane in vitro mikrosomale og hepatocyt - studier resulterer hydrolyse af amidgruppen i den c- terminale aminosyre, phenylalanin, i en deamineret metabolit, og dannelsen af denne metabolit er ikke nadph- afhængig.
mtp (microsomal trigylyceride transfer protein) inhibitors as a class have the potential to disrupt yolk sac development and laboratory studies on rats and rabbits have shown evidence of embryolethality, teratogenicity, and developmental toxicity.
gruppen af mtp (microsomal triglyceride transfer protein)-hæmmere har potentiale til at forstyrre udviklingen af blommesækken, og laboratorieundersøgelser i rotter og kaniner og har vist tegn på at de er embryoletale, teratogene og reproduktionstoksiske.
parathyroid hormone is a natural peptide that is not metabolised by, and does not inhibit hepatic microsomal drug-metabolising enzymes (e.g. cytochrome p450 isoenzymes).
parathyreoideahormon er et naturligt forekommende peptid, som ikke metaboliseres af og ikke hæmmer mikrosomale lægemiddelmetaboliserende leverenzymer (f.eks. cytochrom p450 isoenzymer).
