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endotelīna

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Lettone

Inglese

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Lettone

endotelĪna antagonisti

Inglese

endothelin antagonist

Ultimo aggiornamento 2017-04-26
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Lettone

endotelĪna receptoru antagonisti

Inglese

endothelin receptor antagonist

Ultimo aggiornamento 2017-04-26
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Lettone

var apsvērt alternatīvu endotelīna receptoru antagonistu lietošanu.

Inglese

alternative endothelin receptor antagonists may be considered.

Ultimo aggiornamento 2017-04-26
Frequenza di utilizzo: 1
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Lettone

endotelīna-1 receptoru antagonisti (piemēram, bosentāns)

Inglese

endothelin-1 receptor antagonists (e.g. bosentan)

Ultimo aggiornamento 2017-04-26
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Lettone

opsumit aktīvā viela macitentāns darbojas, bloķējot endotelīna receptorus.

Inglese

the active substance in opsumit, macitentan, works by blocking ‘endothelin receptors’.

Ultimo aggiornamento 2017-04-26
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Lettone

tracleer tabletes pieder zāļu grupai, ko sauc par endotelīna receptoru antagonistiem.

Inglese

tracleer tablets belong to the class of medicines called endothelin receptor antagonists.

Ultimo aggiornamento 2012-04-10
Frequenza di utilizzo: 2
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Lettone

endotelīna receptoru antagonistu klases līdzekļu lietošana var būt saistīta ar aknu funkcijas traucējumiem.

Inglese

endothelin receptor antagonists, as a class, have been associated with liver function abnormalities.

Ultimo aggiornamento 2017-04-26
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Lettone

bloķējot endotelīna iedarbību, tas mazina asinsvadu sašaurināšanos un tādā veida pazemina asinsspiedienu.

Inglese

by blocking the effect of endothelin, it reduces the constriction of the vessels and this helps decrease the blood pressure.

Ultimo aggiornamento 2012-04-10
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Lettone

aknu toksicitātes mehānisms nav pilnībā apstiprināts, un tas var atšķirties starp endotelīna receptoru antagonistiem.

Inglese

the mechanism of liver toxicity is not fully documented and it might vary between endothelin receptor antagonists.

Ultimo aggiornamento 2017-04-26
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Lettone

grauzējiem ilgstoša endotelīna receptoru antagonistu lietošana ir saistīta ar sēklinieku kanāliņu atrofiju un fertilitātes traucējumiem.

Inglese

development of testicular tubular atrophy and impaired fertility has been linked with chronic administration of endothelin receptor antagonists in rodents.

Ultimo aggiornamento 2017-04-26
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Lettone

bloķējot endotelīna iedarbību, volibris ļauj paplašināties asinsvadiem, palīdzot pazemināt asinsspiedienu un novērst simptomus.

Inglese

by blocking the effect of endothelin, volibris allows the vessels to dilate (expand), helping to lower the blood pressure and improving symptoms.

Ultimo aggiornamento 2017-04-26
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Lettone

ambrisentāns ir perorāli aktīvs propionskābes grupas, pret endotelīna a (eta) receptoru selektīvs era.

Inglese

ambrisentan is an orally active, propanoic acid-class, era selective for the endothelin a (eta) receptor.

Ultimo aggiornamento 2017-04-26
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Lettone

nebija atļauts papildus terapijā lietot prostaciklīnu, prostaciklīna analogus un endotelīna receptoru antagonistus, kā arī izmantot arginīna piedevu.

Inglese

the use of prostacyclin, prostacyclin analogues and endothelin receptor antagonists was not permitted as add-on therapy, and neither was arginine supplementation.

Ultimo aggiornamento 2017-04-26
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Lettone

opsumit satur aktīvo vielu macitentānu, kas pieder zāļu grupai, ko sauc par „endotelīna receptoru antagonistiem”.

Inglese

opsumit contains the active substance macitentan, which belongs to the class of medicines called “endothelin receptor antagonists”.

Ultimo aggiornamento 2017-04-26
Frequenza di utilizzo: 1
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Lettone

ar endotelīna receptoru antagonistu (era), tai skaitā ambrisentāna, lietošanu ir bijusi saistīta hemoglobīna koncentrācijas un hematokrīta samazināšanās.

Inglese

reductions in haemoglobin concentrations and haematocrit have been associated with endothelin receptor antagonists (eras) including ambrisentan.

Ultimo aggiornamento 2017-04-26
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Lettone

bosentāns ir divkāršs endotelīna receptora antagonists (era) ar piesaistes spēju endotelīna a un b (eta un etb) receptoriem.

Inglese

bosentan is a dual endothelin receptor antagonist (era) with affinity for both endothelin a and b (eta and etb) receptors.

Ultimo aggiornamento 2017-04-26
Frequenza di utilizzo: 1
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Lettone

sitaksentāna populācija iekļāva arī pacientus (n=53), kuriem izmainītu aknu funkciju dēļ bija pārtraukta citu endotelīna receptoru antagonistu lietošana.

Inglese

the sitaxentan population also included patients (n = 53) who had discontinued another endothelin receptor antagonist due to liver function abnormalities.

Ultimo aggiornamento 2017-04-26
Frequenza di utilizzo: 3
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Lettone

atbilstoša uzmanība jāpievērš gadījumos, kad sitaksentāns tiek nozīmēts pacientiem, kuriem citu endotelīna antagonistu lietošana ir pārtraukta aknu enzīmu izmaiņu dēļ (skatīt apakšpunktu 4. 8).

Inglese

appropriate care should be exercised when initiating sitaxentan in patients who discontinued other endothelin receptor antagonists due to liver enzyme abnormalities (see section 4.8).

Ultimo aggiornamento 2012-04-10
Frequenza di utilizzo: 2
Qualità:

Lettone

atbilstoša uzmanība jāpievērš gadījumos, kad sitaksentāns tiek nozīmēts pacientiem, kuriem citu endotelīna receptoru antagonistu lietošana ir pārtraukta aknu enzīmu līmeņa izmaiņu dēļ (skatīt apakšpunktu 4.8).

Inglese

appropriate care should be exercised when initiating sitaxentan in patients who discontinued other endothelin receptor antagonists due to liver enzyme abnormalities (see section 4.8).

Ultimo aggiornamento 2017-04-26
Frequenza di utilizzo: 1
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Lettone

plaušu hipertensijas un sirds mazspējas gadījumā endotelīnu receptoru antagonisma trūkuma dēļ paaugstinātais et-1 līmenis izteikti korelē ar slimības smagumu un prognozi.

Inglese

in pulmonary arterial hypertension and heart failure, in the absence of endothelin receptor antagonism, elevated et- 1 concentrations are strongly correlated with the severity and prognosis of these diseases.

Ultimo aggiornamento 2017-04-26
Frequenza di utilizzo: 4
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