전문 번역가, 번역 회사, 웹 페이지 및 자유롭게 사용할 수 있는 번역 저장소 등을 활용합니다.
l'invention concerne une nouvelle méthode de conversion d'acides carboxyliques en acides carbothioïques, et l'application de cette méthode dans la préparation de carbothiolates d'androstane, tels que le propionate de fluticasone, sans avoir recours à la chromatographie sur colonne.
this invention discloses a method of conversion of carboxylic acids to carbothiotic acids by reacting a caarbpxylic acid with a first base, an iodide salt, and a compound of formula wherein the variables are as defined in the claims, and reacting the product with a hydrolysing agent and then with an acid. the method is applied to the preparation of androstane carbothiolates, such as fluticasone propionate, which avoids column chromatography.