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dosis af sirolimus bør øges i samme takt, som cyclosporindosis ophører.
the rate at which the dose of sirolimus is increased should correspond to the rate of ciclosporin elimination.

hvis epoetin alfa gives sammen med cyclosporin, skal koncentrationen af cyclosporin i blodet kontrolleres, og cyclosporindosis justeres, når hæmatokritværdien stiger.
if epoetin alfa is given concomitantly with cyclosporin, blood levels of cyclosporin should be monitored and the dose of cyclosporin adjusted as the haematocrit rises.

4. 5) og eller (3) hvis cyclosporindosis reduceres markant eller ophører, da disse patientgrupper mest sandsynligt har specielle doseringskrav.
(1) in patients with hepatic impairment; (2) when inducers or inhibitors of cyp3a4 are concurrently administered and after their discontinuation (see section 4.5); and/ or (3) if ciclosporin dosing is markedly reduced or discontinued, as these populations are most likely to have special dosing requirements.

for at mindske variansen bør sirolimus tages på samme tidspunkt i forhold til cyclosporinindtagelse, 4 timer efter cyclosporindosis og konsekvent med eller uden mad (se pkt.5. 2) .
to minimise variability, rapamune should be taken at the same time in relation to ciclosporin, 4 hours after the ciclosporin dose, and consistently either with or without food (see section 5.2) .

(1) patienter med nedsat hepatisk funktion; (2) når cyp3a4 fremmere eller hæmmere administreres samtidigt og efter deres ophør (se pkt.4. 5) og eller (3) hvis cyclosporindosis reduceres markant eller ophører, da disse patientgrupper mest sandsynligt har specielle doseringskrav.
(1) in patients with hepatic impairment; (2) when inducers or inhibitors of cyp3a4 are concurrently administered and after their discontinuation (see section 4.5); and/or (3) if ciclosporin dosing is markedly reduced or discontinued, as these populations are most likely to have special dosing requirements.