Je was op zoek naar: koagulationskaskaden (Deens - Engels)

hæmning af faktor xa i koagulationskaskaden reducerer trombindannelsen, forlænger størkningstiden og reducerer risikoen for trombedannelse.
inhibition of factor xa in the coagulation cascade reduces thrombin generation, prolongs clotting time and reduces the risk of thrombus formation.

efter aktivering af koagulationskaskaden konverteres faktor viii til aktiveret faktor viii og det frigøres fra von willebrand-faktor.
upon activation of the clotting cascade, factor viii is converted to activated factor viii and released from von willebrand factor.

edoxaban er en højselektiv, direkte og reversibel hæmmer af faktor xa, den serinprotease, der findes i den sidste fælles sti i koagulationskaskaden.
edoxaban is a highly selective, direct and reversible inhibitor of factor xa, the serine protease located in the final common pathway of the coagulation cascade.

da trombin (serinprotease) fremmer ændringen af fibrinogen til fibrin i koagulationskaskaden, vil en hæmning af trombin forhindre udviklingen af tromber.
since thrombin (serine protease) enables the conversion of fibrinogen into fibrin during the coagulation cascade, its inhibition prevents the development of thrombus.

faktor ix aktiveres af faktor vii/vævsfaktorkompleks i den eksterne koagulationskaskade (extrinsic pathway) og af faktor xia i den interne kaskade (intrinsic pathway).
factor ix is activated by factor vii/tissue factor complex in the extrinsic pathway as well as factor xia in the intrinsic coagulation pathway.