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there have been reports of drug interactions with the concomitant use of dextromethorphan and non selective mao inhibitors.
lægemiddelinteraktion er observeret ved samtidig indtagelse af dextromethorfan og non- selektive mao hæmmere.
the exact mechanism by which dextromethorphan exerts therapeutic effects in patients with pseudobulbar affect is unknown.
den nøjagtige mekanisme bag dextromethorphans terapeutiske virkning hos patienter med pseudobulbær affekt kendes ikke.
in such um patients, dextromethorphan is rapidly metabolised, leading to lower, potentially subtherapeutic concentrations.
hos sådanne um-patienter metaboliseres dextromethorphan hurtigt, hvilket medfører lavere, potentielt subterapeutiske koncentrationer.
during celecoxib treatment, the mean plasma concentrations of the cyp2d6 substrate dextromethorphan were increased by 136%.
under behandling med celecoxib steg den gennemsnitlige plasmakoncentration af cyp2d6-substratet dextromethorphan med 136%.
dextromethorphan is rapidly metabolized by cyp2d6 to its primary metabolite, dextrorphan, which is rapidly glucuronidated and renally eliminated.
dextromethorphan metaboliseres hurtigt af cyp2d6 til den primære metabolit dextrorphan, der hurtigt glukuronideres og udskilles renalt.