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production of tnf-a and subsequently periodontal bone loss was also observed by macrophages following tlr2 triggering by oral pathogen (papadopoulos et al, 2012). yet, while the above mechanisms are thought to contribute to the establishment and progression of periodontal disease, animal, and human studies have highlighted the critical role of t cells, particularly cd4+ t cells, in alveolar bone loss (baker et al, 1999).
sel natural killer (nk), sel efektor penting dari respon imun bawaan, terbukti memperburuk periodontitis dengan mensekresi tnf yang mengikat langsung ke patogen oral (chaushu et al, 2012). tnf a adalah sitokin sentral yang secara kritis terlibat dalam patogenesis periodontitis (garlet, 2010).