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in the body, temozolomide is converted to another compound, mtic.
organizme temozolomidas virsta kitu junginiu, mtik (monometil -triazenoimidazolo-karboksamidu) .

mtic 7 westferry circus, canary wharf, london e14 4hb, uk tel.
organizme temozolomidas virsta kitu junginiu – monometilo triazenoimidazolio 7 westferry circus, canary wharf, london e14 4hb, uk tel.

mtic binds to the dna of cells while they are reproducing, and this stops cell division.
mtik prisijungia prie lsteli dnr j dauginimosi metu ir sustabdo lsteli dalijimsi.

temozolomide is a triazene, which undergoes rapid chemical conversion at physiologic ph to the active compound mtic.
10 temozolomidas yra triazenas, kuris fiziologinje ph aplinkoje dl cheminio pokycio greitai virsta veikliuoju junginiu mtik.

the cytotoxicity of mtic is thought to be due primarily to alkylation at the o6 position of guanine with additional alkylation also occurring at the n7 position.
citotoksinis mtik poveikis, manoma, pirmiausiai pasireiskia dl guanino alkilinimo o6 padtyje bei papildomo alkilinimo n7 padtyje.

mtic is spontaneously hydrolyzed to 5-amino- imidazole-4-carboxamide (aic), a known intermediate in purine and nucleic acid biosynthesis, and to methylhydrazine, which is believed to be the active alkylating species.
mtik savaime hidrolizuojamas į 5-amino-imidazol-4- karboksamidą (aik) (žinomą tarpinį junginį purinų ir nukleorūgščių biozintezėje) ir metilhidraziną, kuris, kaip manoma, yra veiksmingas alkilinantis junginys.