Je was op zoek naar: megakaryocytes (Engels - Maltees)

increased bone marrow reticulin is believed to be a result of tpo receptor stimulation, leading to an increased number of megakaryocytes in the bone marrow, which may subsequently release cytokines.
Żjieda fir-reticulin tal-mudullun tal-għadam huwa maħsub li hija riżultat ta’ l-istimulazzjoni tar- riċettur ta’ tpo li twassal għal żjieda fin-numru ta’ magakarjoċiti fil-mudullun tal-għadam li wara jista’ jeħles ċitokini.

in vitro studies of human megakaryocytopoiesis established that anagrelide’s inhibitory actions on platelet formation in man are mediated via retardation of maturation of megakaryocytes, and reducing their size and ploidy.
studji in vitro ta’ megakarjoċitopoeżi umana stabbilixxew li l-azzjonijiet inibitorji ta’ anagrelide fuq il-formazzjoni tal-plejtlets fil-bniedem huma medjati permezz ta’ dewmien fil-maturazzjoni tal- megakarjoċiti, u bi tnaqqis tad-daqs u l-ploidy tagħhom.

kyprolis causes thrombocytopenia through inhibition of platelet budding from megakaryocytes resulting in a classic cyclical thrombocytopenia with platelet nadirs occurring on day 8 or 15 of each 28-day cycle and usually associated with recovery to baseline by the start of the next cycle.
kyprolis jikkawża tromboċitopenija permezz tal-inibizzjoni tas-separazzjoni għat-tkabbir tal-plejtlits mill-megakaryocytes li jirriżulta fi tromboċitopenija ċiklika klassika bl-inqas għadd ta’ plejtlits li jseħħ f’jum 8 jew 15 ta’ kull ċiklu ta’ 28 jum u normalment hija assoċjata mal-irkupru mil-linja bażi sal-bidu taċ-ċiklu li jmiss.

this non-linear decrease in volume of distribution is in line with the (megakaryocyte and platelet) target-mediated binding of romiplostim, which may be saturated at the higher doses applied.
dan it-tnaqqis mhux lineari fil-volum ta’ distribuzzjoni, huwa konsistenti mat-twaħħil ta’ romiplostim medjat mit-targit (megakarjoċiti u plejtlit), li jista’ jkun saturat fl-ogħla dożi mogħtija.