Você procurou por: tumorigenesis (Inglês - Espanhol)

tumorigenesis
transformación celular neoplásica

molecules possibly associated with tumorigenesis and/or tumor cell differentiation
moléculas posiblemente asociadas con la tumorigénesis o la diferenciación celular tumoral

the end result of this process is unrestricted cellular proliferation leading to tumorigenesis.
el resultado final de este proceso es proliferación celular sin restricción lo que lleva a la generación de tumores.

very little is known about the genetic changes involved in the tumorigenesis of postirradiation sarcomas.
se conoce muy poco sobre los cambios genéticos implicados en la tumorogénesis de los sarcomas post-irradiación.

they have been speculated to result from angiogenic processes as opposed to tumorigenesis.[13]
se ha especulado que son el resultado procesos angiogénicos en oposición a la tumorogénesis.[13]

most, if not all, cancer cells contain genetic damage that appears to be the responsible event leading to tumorigenesis.
la mayoría, si no todas, las células cancerosas tienen daño genético que aparece ser responsable de la génesis del tumor.

targeted therapies are different in that they are designed to act only against specific molecular targets that drive tumorigenesis to reverse their specific oncogenic effects.
las terapias dirigidas difieren de la quimioterapia convencional en el hecho de que son diseñadas para actuar únicamente contra dianas moleculares concretas responsables de la transformación tumoral de las células, con el fin de revertir sus efectos oncogénicos específicos.

therefore target tissue bioactivation may lead to the formation of mutagenic metabolites, which may be critical in alachlor-induced rat nasal tumorigenesis.
por consiguiente, la bioactivación del tejido objeto puede llevar a la formación de metabolitos mutagénicos, que pueden ser críticos para la formación de tumores nasales inducidos por el alaclor en ratas.

the bcor alterations may have a role in the tumorigenesis of clear cell sarcoma of the kidney and aid in the differential diagnosis of renal tumors.[2]
las alteraciones en bcor pueden desempeñar una función en la tumorogénesis del sarcoma de células claras del riñón y servir para el diagnóstico diferencial de los tumores renales.[2]

new study reveals important mechanism for tumorigenesis cancer is a complex disease, in which cells undergo a series of alterations, including changes in their architecture; an ...
un nuevo estudio muestra un mecanismo importante en la formación de tumores el cáncer es una enfermedad compleja en la que las células sufren una serie de alteraciones que mod ...

in the case of but, it was decided that since the nel for tumorigenesis is higher than that for haemorrhagic and other toxic effects, the adi should be based on these latter effects, with a standard safety factor of 100.
en el caso de este último, se decidió que ya que el nel para la carcinogénesis es superior al de los efectos hemorrágicos y otros efectos tóxicos, la ingestión diaria aceptable debería basarse en estos últimos efectos con una norma de factor de seguridad igual a 100.

mutations in the region of the telomerase gene that controls its expression were found in various types of thyroid cancers and were most prevalent in aggressive thyroid cancers, suggesting that these mutations may be involved in thyroid tumorigenesis, thyroid cancer progression, and thyroid cancer aggressiveness.
se hallaron mutaciones en la región del gen telomerasa que controla su expresión en diversos tipos de cánceres de tiroides y fueron más prevalentes en los cánceres de tiroides agresivos; esto indicaría que estas mutaciones podrían participar en la oncogenia de la tiroides, y en la evolución y el nivel de agresividad del cáncer de tiroides.

the commonly used antimicrobial additive triclosan is a liver tumor promoter mei-fei yueha , koji taniguchib , shujuan chena , ronald m. evansc , bruce d. hammockd,1, michael karinb , and robert h. tukeya,1 a laboratory of environmental toxicology, departments of chemistry & biochemistry and pharmacology, and b laboratory of gene regulation and signal transduction, department of pharmacology, university of california, san diego, la jolla, ca 92093; c gene expression laboratory, salk institute for biological studies, la jolla, ca 92037; and d department of entomology and nematology and comprehensive cancer center, university of california davis cancer center, university of california, davis, ca 95616 contributed by bruce d. hammock, october 8, 2014 (sent for review june 17, 2014; reviewed by christopher a. bradfield and margaret o. james) triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol; tcs] is a synthetic, broad-spectrum antibacterial chemical used in a wide range of consumer products including soaps, cosmetics, therapeutics, and plastics. the general population is exposed to tcs because of its prevalence in a variety of daily care products as well as through waterborne contamination. tcs is linked to a multitude of health and environmental effects, ranging from endocrine disruption and impaired muscle contraction to effects on aquatic ecosystems. we discovered that tcs was capable of stimulating liver cell proliferation and fibrotic responses, accompanied by signs of oxidative stress. through a reporter screening assay with an array of nuclear xenobiotic receptors (xenors), we found that tcs activates the nuclear receptor constitutive androstane receptor (car) and, contrary to previous reports, has no significant effect on mouse peroxisome proliferation activating receptor α (pparα). using the procarcinogen diethylnitrosamine (den) to initiate tumorigenesis in mice, we discovered that tcs substantially accelerates hepatocellular carcinoma (hcc) development, acting as a liver tumor promoter. tcs-treated mice exhibited a large increase in tumor multiplicity, size, and incidence compared with control mice. tcsmediated liver regeneration and fibrosis preceded hcc development and may constitute the primary tumor-promoting mechanism through which tcs acts. these findings strongly suggest there are adverse health effects in mice with long-term tcs exposure, especially on enhancing liver fibrogenesis and tumorigenesis, and the relevance of tcs liver toxicity to humans should be evaluated. triclosan | liver fibrosis | tumor promoter | hepatocellular carcinoma triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol, tcs] is a broad-spectrum antimicrobial agent ubiquitously used in personal care, household cleaning, and general consumer products (1). originally developed in 1972 as an antibacterial component in a surgical scrub formation, tcs is structurally similar to brominated diphenyl ethers, is generally accepted as welltolerated and safe, and has become one of the most common additives to many consumer products, including disinfectants, soap, shampoo, detergent, toothpaste, mouthwash, deodorant, and even textiles. a substantial increase of tcs use has occurred during the last 20 y, resulting in widespread environmental pollution and its detection in waterways and the biological fluids of wild animals (2). in fact, tcs is listed among the seven most frequently detected compounds in streams across the united states, and ∼1,500 tons continue to be produced annually worldwide (3). once it has entered the body, tcs is mainly detoxified through glucuronidation by udp-glucuronyltransferases (4). recent studies have revealed that tcs is capable of interfering with various hormones as a weak endocrine disruptor in multiple species (5), as well as of impairing muscle contraction (6). tcs was tested in several cell-based genotoxicity assays with no detectable mutagenic activity; nonetheless, the potential carcinogenicity of tcs in vivo has been largely unexplored. previous animal data in rodents indicate that hepatocyte hypertrophy and vacuolization occurred after tcs ingestion, and its action has been proposed to be mediated through peroxisome proliferation activating receptor α (pparα), a mode of action considered to be irrelevant to humans (2). to clarify the involvement of nuclear receptors, including pparα, in tcs-mediated responses, we first implemented a high-throughput xenobiotic nuclear receptor (xenor) screening assay. our studies indicate that ppar activation is not relevant to the toxic effects of tcs in mice. however, long-term tcs treatment of mice led to hepatic cell proliferation, hepatocyte fibrosis, and oxidative stress. on the basis of the belief that liver fibrosis, when advanced, is a risk factor for developing hepatocellular carcinoma (hcc) (7), we also carried out a tumor promotion study in which tcs treatment was preceded by administration of a tumor initiator diethylnitrosamine (den). this study documents the molecular and biochemical events regarding tcs-mediated fibrogenesis and demonstrates that tcs acts as a promoter of hcc development. the mechanism of tcs-induced hepatic tumorigenesis in mice may be relevant to humans. materials and methods animals. male c57bl/6 mice (3 wk old) were fed with a chow diet containing either 0.08% tcs (n = 6) or no tcs (n = 6). after 8 mo of tcs treatment, mice were killed and their livers were removed and were subject to analysis of gene expression and histological and immunochemical parameters. the car-null (car−/−) mouse line was a generous gift from masahiko negishi (national institute of environmental health sciences), and genotyping for car-null mice was described previously (8). in the study of constitutive significance triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol; tcs] is a broadspectrum antimicrobial agent that has become one of the most common additives used in consumer products. as a result, tcs has significantly affected the environment and has been frequently detected in human body fluids. through a long-term feeding study, we found that tcs enhances hepatocyte proliferation, fibrogenesis, and oxidative stress, which, we believe, can be the driving force for developing advanced liver disease in mice. indeed, tcs strongly enhances hepatocarcinogenesis after diethylnitrosamine initiation, accelerating hepatocellular carcinoma (hcc) development. although animal studies require higher chemical concentrations than predicted for human exposure, this study demonstrates that tcs acts as a hcc tumor promoter and that the mechanism of tcs-induced mouse liver pathology may be relevant to humans.
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