Вы искали: tissue factor pathway inhibitor (Английский - Мальтийский)

the mechanism of action includes the binding of factor viia to exposed tissue factor.
il-mekkaniżmu ta’ kif jaħdem jinkludi r-rabta tal-fattur viia mal-fattur tat-tessuti espost.

factor ix is activated by factor xia in the intrinsic coagulation pathway and by factor vii/tissue factor complex in the extrinsic pathway.
fattur ix jiġi attivat minn fattur xia fil-passaġġ intrinsiku ta' koagulazzjoni u minn fattur vii/fattur tat-tessut fil-passaġġ estrinsiku.

factor ix is activated by factor vii/tissue factor complex in the extrinsic pathway as well as factor xia in the intrinsic coagulation pathway.
il- fattur ix hu attivat permezz tal-kumpless tal-fattur vii/fattur tat-tessut fil-passaġġ estrinsiku, kif ukoll permezz tal-fattur xia fil-passaġġ intrinsiku tal-koagulazzjoni.

this results in the conversion of prothrombin into large amounts of thrombin independently of tissue factor.
dan jirriżulta fil-konverżjoni ta’ prothrombin f’ammonti kbar ta’ thrombin indipendentement mill-fattur tat-tessuti.

pharmacological doses of novoseven activate factor x directly on the surface of activated platelets, localized to the site of injury, independently of tissue factor.
dożi farmakoloġiċi ta’ novoseven jattivaw il-fattur x direttament fuq il-wiċċ tal-plejtlets attivati, li jkunu lokalizzati fis-sit tal-ferita, indipendentement mill-fattur tat-tessut.

the factors most strongly inhibited are thrombin and factor xa, but also factors of contact activation, intrinsic system and the factor viia/ tissue factor complex.
wkoll il- fatturi ta 'l attivazzjoni tal- kuntatt, sistema intrinsika u l fattur viia/ kumpless tal -

these include atiii-dependent inhibition of other coagulation factors like factor viia, induction of endogenous tissue factor pathway inhibitor (tfpi) release as well as a reduced release of von willebrand factor (vwf) from the vascular endothelium into the blood circulation.
dawn jinkludu inibizzjoni li tiddependi fuq il-atiii ta' fatturi koagulanti oħrajn bħall-fattur viia, induzzjoni tar-rilaxx tal-inibitur tal-passaġġ tal-fattur tat-tessut endoġenu (tfpi) kif ukoll tnaqqis fir-rilaxx ta' fattur von willebrand (vwf) mill-endothelium vaskulari fiċ-ċirkolazzjoni vaskulari.

in pathological conditions in which tissue factor may be expressed more extensively than considered normal, there may be a potential risk of development of thrombotic events or induction of disseminated intravascular coagulation (dic) in association with novoseven treatment.
f’kundizzjonijiet patoloġiċi li fihom il-fattur tat-tessut jista’ jiġi espress b’mod aktar estensiv minn dak li huwa kkunsidrat bħala normali, jista’ jkun hemm riskju potenzjali ta’ l-iżvilupp ta’ avvenimenti trombotiċi jew li jkun hemm koagulazzjoni intravaskulari disseminata (disseminated intravascular coagulation-dic) meta tingħata l-kura ta’ novoseven.

hedgehog pathway inhibitors (see section 5.1) such as vismodegib, have been demonstrated to be embryotoxic and/or teratogenic in multiple animal species and can cause severe malformations, including craniofacial anomalies, midline defects and limb defects (see section 5.3).
inibituri tar-rotta hedgehog (ara sezzjoni 5.1) bħal vismodegib intwerew li huma embrijotossiċi u/jew teratoġeniċi f’ħafna speċi ta’ annimali u jistgħu jikkawżaw malformazzjonijiet severi, inkluż anomaliji fil-kranju u l-wiċċ, difetti fil-linja tan-nofs u difetti fir-riġlejn u d-dirgħajn (ara sezzjoni 5.3).