您搜索了: guanín (斯洛伐克语 - 英语)

guanín
guanine

guanín (ci 75170)
guanine (ci 75170)

guanín (cas rn 73-40-5)
guanine (cas rn 73-40-5)

okrem toho sa časť nelarabínu hydrolyzuje na metylguanín, ktorý sa o-demetyluje na guanín.
in addition, some nelarabine is hydrolysed to form methylguanine, which is o-demethylated to form guanine.

prvý krok je katalyzovaný hypoxantín-guanín-fosforibozyltransferázou, pričom sa vytvorí tioinozínmonofosfát (timp).
the first step is catalysed by hypoxanthine-guanine phosphoribosyl transferase yielding thioinosine monophosphate (timp).

2-amino-1,7-dihydro-6h-purín-6-ón; guanín
2-amino-1,7-dihydro-6h-purin-6-one; guanine

hlavná metabolická dráha nelarabínu je o-demetylácia adenozíndeaminázou, ktorá vedie k tvorbe ara-g, ktorý sa hydrolyzuje na guanín.
the principal route of metabolism for nelarabine is o-demethylation by adenosine deaminase to form ara-g, which undergoes hydrolysis to form guanine.

z toho dôvodu sa teoreticky nemá podávať u pacientov so zriedkavou dedičnou deficienciou hypoxantín- guanín - fosforibozyltransferázy (hgprt) ako je lesch- nyhanov a kelley- seegmillerov syndróm.
on theoretical grounds, therefore, it should be avoided in patients with rare hereditary deficiency of hypoxanthine-guanine phosphoribosyl-transferase (hgprt) such as lesch-nyhan and kelley-seegmiller syndrome.