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tracheo-oesophageal malformations (e.g. oesophageal atresia);
vanskapanir á barka og vélinda (t.d. vélindalokun (oesophageal atresia));
Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:
abnormalities of the ear (e.g. abnormally formed or absent external/middle ear), external auditory canal atresia;
vanskapanir á eyrum (t.d. óeðlilega lagað eða ekkert ytra eyra/miðeyra), lokun á hlust;
Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:
however, testicular (hypocellularity of the seminiferous epithelium) and ovarian changes (follicular atresia) were observed in repeated-dose toxicity studies in animals at exposures 11 to 15 times (rat) or 0.6 to 7 times (monkey) the anticipated clinical exposure (based on auc) at the maximum tolerated human dose.
hins vegar hafa breytingar í eistum (frumnafæð í þekjuvef sáðpípla) og eggjastokkum (stöðvun þroska eggbúa) komið fram í rannsóknum á endurteknum skömmtum hjá dýrum við útsetningu sem er 11 til 15-föld (rottur) eða 0,6 til 7-föld (apar) áætluð klínísk útsetning (samkvæmt auc) við hámarksskammt sem þolist hjá mönnum.
Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit: