Results for hydroxybupropion translation from English to Portuguese

hydroxybupropion: auc: +--
hidroxibupropiom: auc: +

buproprion and its active metabolite, hydroxybupropion:
bupropiom e o seu metabolito ativo, hidroxibupropiona:

bupropion is metabolised to its major active metabolite hydroxybupropion primarily by the cyp2b6 isozyme.
o bupropiom é metabolizado no seu principal metabolito ativo – hidroxibupropiom – pela isoenzima cyp2b6.

bupropion is extensively metabolised with three active metabolites: hydroxybupropion, threohydrobupropion and erythrohydrobupropion.
o bupropiom é extensivamente metabolizado com três metabolitos ativos: hidroxibupropiom, treohidrobupropiom e eritrohidrobupropiom.

in healthy subjects, prasugrel decreased exposure to hydroxybupropion, a cyp2b6-mediated metabolite of bupropion, by 23%.
em indivíduos saudáveis, o prasugrel diminuiu em cerca de 23% a exposição ao cloridrato de bupropiom, um metabolito do bupropiom mediado em cerca de 23% pelo cyp2b6.

although not metabolised by the cyp2d6 isoenzyme, bupropion and its main metabolite, hydroxybupropion, inhibit the cyp2d6 pathway and the potential exists to affect medicinal products metabolised by cyp2d6.
apesar de não serem metabolizados pela isoenzima cyp2d6, o bupropiom e o seu principal metabolito, hidroxibupropiom, inibem a via da cyp2d6 e existe potencial para afetar fármacos metabolizados pela cyp2d6.

bupropion is metabolised to its major active metabolite hydroxybupropion primarily by the cytochrome p450 cyp2b6; thus, the potential exists for interaction when administered with medicinal products that induce or inhibit cyp2b6.
o bupropiom é metabolizado no seu principal metabolito ativo hidroxibupropiom especialmente pelo citocromo p 450 cyp2b6; por conseguinte, existe potencial para a interação aquando da administração com fármacos indutores ou inibidores do cyp2b6.

the clinical consequences of the inhibition of the metabolism of bupropion via cyp2b6 enzyme and the consequent changes in the bupropion-hydroxybupropion ratio are currently unknown, but could potentially lead to reduced efficacy of naltrexone / bupropion.
as consequências clínicas da inibição do metabolismo do bupropiom via enzima cyp2b6 e as consequentes alterações no rácio bupropiom/hidroxibupropiom são atualmente desconhecidas, mas podem levar potencialmente a uma eficácia reduzida da associação naltrexona/bupropiom.

bupropion: in healthy volunteers, the auc and cmax of bupropion and of its active metabolite, hydroxybupropion, were decreased by about 50% when co-administered with lopinavir/ ritonavir capsules 400/ 100 mg twice daily at steady-state.
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